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Go Bayesian. Choose from various MCMC and Nested Sampling algorithms (static/dynamic, multinest, polychord, slicing).
Powered by emcee (Foreman-Mackey et al., 2013) and dynesty (Speagle; GitHub).
MCMC sketch: Yardim et al., 2006
Nested Sampling sketch: Feroz et al., 2013
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